Autonomic Nervous System Discussion Solutions

Autonomic Nervous System Discussion Solutions
Autonomic Nervous System Discussion Solutions
Questions: I-1 Pharmacokinetics
Di culty level: Easy
1. A 22-year-old wom an su ering from asthm a was prescribed
albuterol by inhalation. Albuterol is a bronchodilating drug
w ith a m olecular w eight of 239 daltons. W hich of the follow ing perm eation processes m ost likely accounted for the
transfer of the drug through the bronchial m ucosa?
A. Aqueous di usion
B. Lipid di usion
C. Facilitated di usion
D. Endocytosis
E. Active transport
Di culty level: Easy
Autonomic Nervous System Discussion Solutions
2. A 34-year-old m an on vacation in Mexico was adm itted to the
hospital because of vom iting, double vision, and m uscular paralysis. The m an reported that he had eaten som e canned food
from a local vendor the previous day. After a physical examination, a presum ptive diagnosis of botulism was m ade. It is
know n that botulinum toxin causes paralysis by getting inside the axon term inals of m otor nerves, w here it inhibits the
release of acetylcholine. Botulinum toxin is a protein w ith a
m olecular weight greater than 100,000 daltons. Which of the
follow ing perm eation processes m ost likely accounts for the
transfer of the toxin through the nerve cell m em brane?
A. Aqueous di usion
B. Lipid di usion
C. Facilitated di usion
D. Endocytosis
E. Filtration
Di culty level: Easy
3. A 51-year-old wom an su ering from hyperthyroidism was
adm inistered an oral solution of radioactive iodine to destroy
her thyroid gland. Which of the follow ing perm eation processes m ost likely accounted for the transfer of the drug across
the thyroid cell m em brane?
A. Active transport
B. Lipid di usion
C. Facilitated di usion
D. Endocytosis
E. Aqueous di usion
Di culty level: Easy
4. A 12-year-old boy recently diagnosed w ith type 1 diabetes
started a therapy w ith two daily subcutaneous adm inistrations
of insulin. Which of the follow ing perm eation processes best
explains the absorption of insulin from the site of injection?
A. Bulk ow transport
B. Lipid di usion
C. Facilitated di usion
D. Endocytosis
E. Active transport
Di culty level: Hard
5. An 85-year-old m an was recently adm itted to a nursing facility. Diseases listed in his m edical record on adm ission were
depression w ith anxiet y sym ptom s, atrial brillation, chronic
obstructive pulm onary disease, and osteoarthritis. Medications taken orally by the patient included the follow ing:
Sertraline (base, pK
a = 9.5)
Diazepam (base, pK
a = 3.0)
Am iodarone (base, pK
a = 7.4)
Theophylline (acid, pK
a = 8.8)
Ibuprofen (acid, pK
a 4.8)
Shortly after adm inistration, w hich of the follow ing drugs was
m ost likely concentrated inside the patient’s gastric cells?
A. Sertraline
B. Diazepam
C. Am iodarone
D. Theophylline
E. Ibuprofen
Di culty level: Medium
6. A 17-year-old boy took a tablet of naproxen for a headache.
Naproxen is a weak acid w ith a pK
a of 5.2. W hat percentage
of the drug was m ost likely w ater soluble in the patient’s
plasm a?
A. 1%
B. 24%
C. 50%
D. 76%
E. 99%
F. > 99%
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