Introduction to Central Nervous System Pharmacology

Introduction to Central Nervous System Pharmacology
Introduction to Central Nervous System Pharmacology
Di culty level: Easy
1. A 3-year-old boy was brought to the em ergency departm ent
after eating som e black berries from a plant in the woods.
Physical exam ination showed a disoriented and hallucinating
patient w ith dilated pupils, dry m outh, red and dry skin, and
body tem perature of 103.4°F (39.7°C). Vital signs were blood
pressure 90/50 m m Hg, pulse 122 bpm , respirations 24/m in.
The central and peripheral sym ptom s of this patient were
m ost likely m ediated by the blockade of w hich of the following receptors?
A. Noradrenergic
B. Nicotinic
C. Muscarinic
D. Dopam inergic
E. Serotonergic
F. GABAergic
G. Glutam atergic
Di culty level: Hard
2. A 33-year-old m an w ho was a heavy sm oker started a m edically assisted program to quit sm oking. Therapy included the
adm inistration of an agonist at α2 presynaptic receptors that
acts m ainly on noradrenergic neurons in the brain. Which of
the follow ing brain regions was m ost likely involved in the
therapeutic e ect of the drug in this patient?
A. Nucleus basalis of Meynert
B. Central raphe nucleus
C. Locus ceruleus
D. Substantia nigra
E. Amygdala
F. Nucleus tractus solitarius
Di culty level: Medium
3. A 46-year-old wom an com plained to her physician of daytim e sleepiness. One day earlier, she had started taking an
antihistam ine for allergic rhinitis. The physician explained
that drowsiness was m ost likely due to inhibition of the action
of histam inergic neurons in the brain. Which of the follow ing
brain regions was m ost likely involved in the adverse e ect of
this drug?
A. Nucleus tractus solitarius
B. Caudatum
C. Hippocampus
D. Nucleus basalis of Meynert
E. Amygdala
F. Ventral posterior hypothalam us
Di culty level: Medium
4. A 51-year-old m an su ering from episodic leg cram ps started
a treatm ent w ith a drug that activates GABAB receptors both
in the brain and in the spinal cord. This activation m ost likely
opened w hich of the follow ing ion channels?
A. K
B. Cl−
C. Ca2
D. Mg
E. Na
Di culty level: Easy
5. A 54-year-old wom an su ering from initial insom nia was
prescribed a hypnotic drug that increases the activit y of a
m ajor neurotransm itter system in the brain. Which of the follow ing neurotransm itter system s was m ost likely involved in
the therapeutic action of that drug?
A. Cholinergic
B. Noradrenergic
C. Glutam atergic
D. GABAergic
E. Dopam inergic
F. Endorphinergic
Di culty level: Medium
6. A 54-year-old wom an was adm itted unconscious to the em ergency departm ent after a car accident. After physical and lab
exam s, a diagnosis of brain injury was m ade. It is know n that
in brain injury, a rapid and large increase of Ca2 in ux into
dam aged neurons can contribute signi cantly to neuronal
death (a process called excitotoxicity). Activation of w hich of
the follow ing brain receptors m ost likely caused this m etabolic derangem ent in the patient?
A. Presynaptic α2 adrenoceptors
B. Postsynaptic α2 adrenoceptors
C. Presynaptic NMDA receptors
D. Postsynaptic NMDA receptors
E. Presynaptic GABA receptors
F. Postsynaptic GABA receptors
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