Order Antimicrobial Drugs Discussion Questions

Order Antimicrobial Drugs Discussion Questions
Order Antimicrobial Drugs Discussion Questions
CHOOSE THE MOST APPROPRIATE RESPONSE
47.1 Choose the antimicrobial which acts by interfering
with DNA function in the bacteria:
A. Chloramphenicol
B. Ciprofloxacin
C. Streptomycin
D. Vancomycin (p. 628)
47.2 Which antibiotic is primarily bacteriostatic but
becomes bactericidal at higher concentrations:
A. Erythromycin
B. Tetracycline
C. Chloramphenicol
D. Ampicillin (p. 629)
47.3 Select the antibiotic that has a high therapeutic
index:
A. Streptomycin
B. Doxycycline
C. Cephalexin
D. Vancomycin (p. 629)
47.4 The following organism is notorious for developing
antimicrobial resistance rapidly:
A. Streptococcus pyogenes
B. Meningococcus
C. Treponema pallidum
D. Escherichia coli (p. 630)
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Antimicrobial Drugs
Order Antimicrobial Drugs Discussion Questions
47.1 4 7 . 1 B 47.2 4 7 . 2 A 47.3 4 7 . 3 C 47.4 4 7 . 4 D
Antimicrobial Drugs 319
47.5 Widespread and prolonged use of an antibiotic leads
to emergence of drug resistant strains because
antibiotics:
A. Induce mutation in the bacteria
B. Promote conjugation among bacteria
C. Allow resistant strains to propagate preferentially
D. All of the above (p. 630, 631)
47.6 The most important mechanism of concurrent
acquisition of multidrug resistance among bacteria
is:
A. Mutation
B. Conjugation
C. Transduction
D. Transformation (p. 631)
47.7 Drug destroying type of bacterial resistance is
important for the following antibiotics except:
A. Cephalosporins
B. Tetracyclines
C. Chloramphenicol
D. Aminoglycosides (p. 631,670)
47.8 Acquisition of inducible energy dependent efflux
proteins by bacteria serves to:
A. Secrete exotoxins
B. Enhance virulance
C. Lyse host tissue
D. Confer antibiotic resistance (p. 631)
47.5 4 7 . 5 C 47.6 4 7 . 6 B 47.7 4 7 . 7 B 47.8 4 7 . 8 D
320 MCQs in Pharmacology 320
47.9 Methicillin resistant staphylococci do not respond to
β-lactam antibiotics because:
A. They produce a β-lactamase which destroys
methicillin and related drugs
B. They elaborate an amidase which destroys
methicillin and related drugs
C. They have acquired penicillin binding protein which has low affinity for β-lactam antibiotics
D. They are less permeable to β-lactam antibiotics (p. 659)
47.10 The following strategy will promote rather than curb
emergence of antibiotic resistant micro-organisms:
A. Whenever possible use broad spectrum antibiotics
B. Prefer a narrow spectrum antibiotic to a broad
spectrum one if both are equally effective
C. Prefer short and intensive courses of antibiotics
D. Use antibiotic combinations for prolonged
therapy (p. 632)
Order Antimicrobial Drugs Discussion Questions
47.11 Superinfections are more common with:
A. Use of narrow spectrum antibiotics
B. Short courses of antibiotics
C. Use of antibiotics that are completely absorbed from the small intestines
D. Use of antibiotic combinations covering both
gram positive and gram negative bacteria
(p. 632)
47.9 4 7 . 9 C 47.10 4 7 . 1 0 A 47.11 4 7 . 1 1 D
Antimicrobial Drugs 321
47.12 The following organisms are frequently responsible
for superinfections except:
A. Pseudomonas aeruginosa
B. Salmonella typhi
C. Clostridium difficile
D. Candida albicans (p. 633)
47.13 Select the antibiotic whose dose must be reduced in
patients with renal insufficiency:
A. Ampicillin
B. Chloramphenicol
C. Tobramycin
D. Erythromycin (p. 633)
47.14 Which antimicrobial should be avoided in patients of
liver disease:
A. Tetracycline
B. Cotrimoxazole
C. Cephalexin
D. Ethambutol (p. 634)
Order Antimicrobial Drugs Discussion Questions
47.15 What is break point concentration of an antibiotic:
A. Concentration at which the antibiotic lyses
the bacteria
B. Concentration of the antibiotic which demarkates between sensitive and resistant
bacteria
C. Concentration of the antibiotic which overcomes bacterial resistance
D. Concentration at which a bacteriostatic antibiotic becomes bactericidal (p. 635)
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