Proenkephaline as a new Kidney Marker

DescriptionManuscript about a clinical study of nephrological markers of kidney function with the title „proenkephaline as a new kidney marker compared with creatinine“.

The manuscript should explain a clinical study. In this clinical study we have investigated 200 patients before and after cardiac surgery and we have made a follow-up with blood withdrawals at ten time-points before and after cardiac surgery. We then investigated whether or not the novel blood marker proenkephaline can predict the clinical outcome in detail the kidney function. For patients with cardiac surgery the most important complication is renal failure because of the cardiorenal syndrome. So it is most important to early detect the patients which will get a kidney failure and we hope that this novel marker can help us to find these patients early. So we need an introduction with some literature search done on what is the up-to-date state of the art and with an update about the latest developments in kidney markers in the context of cardiac surgery. Then we need a materials and methods section. The measurements were done from EDTA plasma. Plasma was centrifuged and stored at -80°C. Measured with an ELISA. And then we need the results section which shows a high degree of similarity between creatinine and proencephaline measurement results. For patients with a pre-existing chronic renal failure we see a high sharpness of separation of the groups which later on develop a kidney failure. For patients with acute kidney injury AKI we see a trend. And we need some conclusions and these conclusions should say that this new marker is a promising new marker.