The pharmacokinetic process of absorption

Week 3 Objectives / Concepts for 215 Chapter 4 Chapter 5 Define pharmacokinetics Discuss the pharmacokinetic process of absorption.Discuss the advantages and disadvantages of intravenous drug administrationDiscuss the advantages and disadvantages of intramuscular drug administrationDiscuss the advantages and disadvantages of oral drug administrationDescribe: tablets vs. enteric coated tablets vs. sustained release tablets. Discuss the advantages and disadvantages of intravenous drug administration Discuss the advantages and disadvantages of intramuscular drug administration Discuss the advantages and disadvantages of oral drug administration Describe: tablets vs. enteric coated tablets vs. sustained release tablets. Discuss the pharmacokinetic process of distribution.Describe blood flow to tissues and the ability of a drug to exit the vascular system and enter cells.Define and describe the Blood-Brain barrierDiscuss the significance of placental drug transferDiscuss the significance of albumin in relation to protein binding Describe blood flow to tissues and the ability of a drug to exit the vascular system and enter cells. Define and describe the Blood-Brain barrier Discuss the significance of placental drug transfer Discuss the significance of albumin in relation to protein binding Discuss the pharmacokinetic process of metabolism and the significance of the liver.Discuss the significance of the hepatic microsomal enzyme system (aka P450 system)Define and describe the first pass effect. Discuss the significance of the hepatic microsomal enzyme system (aka P450 system) Define and describe the first pass effect. Discuss the pharmacokinetic process of excretion and the significance of the kidney.Discuss the relevance of excretion of a drug from the body and the routes by which a drug may be excreted. Discuss the relevance of excretion of a drug from the body and the routes by which a drug may be excreted. Define and describe the following:Plasma drug levelThe therapeutic rangeSingle-dose time courseDrug half-life. Plasma drug level The therapeutic range Single-dose time course Drug half-life. Explain the need to sometimes monitor plasma drug levels and describe how these levels are regulated to prevent drug toxicity. Identify the two factors that largely determine the duration of a single-dose time course and compare drugs with short half-lives versus those with long half-lives. Discuss the negative effects of repeated drug doses. Define pharmacodynamics and its relationship to the action of drugs on the body. Describe the concept of dose-response relationships; and its relationship to both maximal efficacy and relative potency. Describe a drug-receptor interaction. Describe what is meant by selective drug action Define and describe affinity and intrinsic infinity Define and describe the following: agonists antagonists and partial agonists. Discuss and describe interpatient variability; and describe how to measure variability. Define the ED50 and the LD50. Discuss the concept of a drug’s therapeutic index and its application to clinical practice. Define pharmacokineticsDiscuss the pharmacokinetic process of absorption.Discuss the advantages and disadvantages of intravenous drug administrationDiscuss the advantages and disadvantages of intramuscular drug administrationDiscuss the advantages and disadvantages of oral drug administrationDescribe: tablets vs. enteric coated tablets vs. sustained release tablets.Discuss the pharmacokinetic process of distribution.Describe blood flow to tissues and the ability of a drug to exit the vascular system and enter cells.Define and describe the Blood-Brain barrierDiscuss the significance of placental drug transferDiscuss the significance of albumin in relation to protein bindingDiscuss the pharmacokinetic process of metabolism and the significance of the liver.Discuss the significance of the hepatic microsomal enzyme system (aka P450 system)Define and describe the first pass effect.Discuss the pharmacokinetic process of excretion and the significance of the kidney.Discuss the relevance of excretion of a drug from the body and the routes by which a drug may be excreted.Define and describe the following:Plasma drug levelThe therapeutic rangeSingle-dose time courseDrug half-life. Discuss the advantages and disadvantages of intravenous drug administrationDiscuss the advantages and disadvantages of intramuscular drug administrationDiscuss the advantages and disadvantages of oral drug administrationDescribe: tablets vs. enteric coated tablets vs. sustained release tablets. Describe blood flow to tissues and the ability of a drug to exit the vascular system and enter cells.Define and describe the Blood-Brain barrierDiscuss the significance of placental drug transferDiscuss the significance of albumin in relation to protein binding Discuss the significance of the hepatic microsomal enzyme system (aka P450 system)Define and describe the first pass effect. Discuss the relevance of excretion of a drug from the body and the routes by which a drug may be excreted. Plasma drug levelThe therapeutic rangeSingle-dose time courseDrug half-life. Explain the need to sometimes monitor plasma drug levels and describe how these levels are regulated to prevent drug toxicity.Identify the two factors that largely determine the duration of a single-dose time course and compare drugs with short half-lives versus those with long half-lives.Discuss the negative effects of repeated drug doses. Define pharmacodynamics and its relationship to the action of drugs on the body.Describe the concept of dose-response relationships; and its relationship to both maximal efficacy and relative potency.Describe a drug-receptor interaction.Describe what is meant by selective drug actionDefine and describe affinity and intrinsic infinityDefine and describe the following: agonists antagonists and partial agonists.Discuss and describe interpatient variability; and describe how to measure variability.Define the ED50 and the LD50.Discuss the concept of a drug’s therapeutic index and its application to clinical practice.

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