W332615.pdf

Aldrich – W332615
Page 1 of 12

The life science business of Merck KGaA, Darmstadt, Germany

operates as MilliporeSigma in the US and Canada

SAFETY DATA SHEET

Version 8.3
Revision Date 04/23/2021

Print Date 05/23/2021

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers

Product name : Acetone

Product Number : W332615

Brand : Aldrich

Index-No. : 606-001-00-8

CAS-No. : 67-64-1

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Synthesis of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Inc.

3050 Spruce Street

ST. LOUIS MO 63103

UNITED STATES OF AMERICA (THE)

Telephone : +1 314 771-5765

Fax : +1 800 325-5052

1.4 Emergency telephone

Emergency Phone # : 800-424-9300 CHEMTREC (USA) +1-703-

527-3887 CHEMTREC (International) 24

Hours/day; 7 Days/week

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)

Flammable liquids (Category 2), H225

Eye irritation (Category 2A), H319

Specific target organ toxicity – single exposure (Category 3), Central nervous system, H336

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 GHS Label elements, including precautionary statements

Pictogram

Signal word Danger

Aldrich – W332615
Page 2 of 12

The life science business of Merck KGaA, Darmstadt, Germany

operates as MilliporeSigma in the US and Canada

Hazard statement(s)

H225 Highly flammable liquid and vapor.

H319 Causes serious eye irritation.

H336 May cause drowsiness or dizziness.

Precautionary statement(s)

P210 Keep away from heat/ sparks/ open flames/ hot surfaces. No

smoking.

P233 Keep container tightly closed.

P240 Ground/bond container and receiving equipment.

P241 Use explosion-proof electrical/ ventilating/ lighting/ equipment.

P242 Use only non-sparking tools.

P243 Take precautionary measures against static discharge.

P261 Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.

P264 Wash skin thoroughly after handling.

P271 Use only outdoors or in a well-ventilated area.

P280 Wear protective gloves/ eye protection/ face protection.

P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated

clothing. Rinse skin with water/ shower.

P304 + P340 + P312 IF INHALED: Remove person to fresh air and keep comfortable

for breathing. Call a POISON CENTER/ doctor if you feel unwell.

P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes.

Remove contact lenses, if present and easy to do. Continue

rinsing.

P337 + P313 If eye irritation persists: Get medical advice/ attention.

P370 + P378 In case of fire: Use dry sand, dry chemical or alcohol-resistant

foam to extinguish.

P403 + P233 Store in a well-ventilated place. Keep container tightly closed.

P403 + P235 Store in a well-ventilated place. Keep cool.

P405 Store locked up.

P501 Dispose of contents/ container to an approved waste disposal

plant.

2.3 Hazards not otherwise classified (HNOC) or not covered by GHS – none

SECTION 3: Composition/information on ingredients

3.1 Substances

Formula : C3H6O

Molecular weight : 58.08 g/mol

CAS-No. : 67-64-1

EC-No. : 200-662-2

Index-No. : 606-001-00-8

Component Classification Concentration

acetone

Flam. Liq. 2; Eye Irrit. 2A;

STOT SE 3; H225, H319,

H336

Concentration limits:

>= 20 %: STOT SE 3,

H336;

<= 100 % Aldrich - W332615 Page 3 of 12 The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the US and Canada For the full text of the H-Statements mentioned in this Section, see Section 16. SECTION 4: First aid measures 4.1 Description of first-aid measures General advice Consult a physician. Show this material safety data sheet to the doctor in attendance.Move out of dangerous area. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. 4.2 Most important symptoms and effects, both acute and delayed The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11 4.3 Indication of any immediate medical attention and special treatment needed No data available SECTION 5: Firefighting measures 5.1 Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. 5.2 Special hazards arising from the substance or mixture Carbon oxides 5.3 Advice for firefighters Wear self-contained breathing apparatus for firefighting if necessary. 5.4 Further information Use water spray to cool unopened containers. SECTION 6: Accidental release measures 6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. For personal protection see section 8. Aldrich - W332615 Page 4 of 12 The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the US and Canada 6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. 6.3 Methods and materials for containment and cleaning up Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet- brushing and place in container for disposal according to local regulations (see section 13). 6.4 Reference to other sections For disposal see section 13. SECTION 7: Handling and storage 7.1 Precautions for safe handling Advice on safe handling Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Advice on protection against fire and explosion Use explosion-proof equipment.Advice on protection against fire and explosion Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge. Hygiene measures Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. For precautions see section 2.2. 7.2 Conditions for safe storage, including any incompatibilities Storage conditions Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Storage class (TRGS 510): 3: Flammable liquids 7.3 Specific end use(s) Apart from the uses mentioned in section 1.2 no other specific uses are stipulated SECTION 8: Exposure controls/personal protection 8.1 Control parameters Ingredients with workplace control parameters Component CAS-No. Value Control parameters Basis acetone 67-64-1 TWA 250 ppm USA. ACGIH Threshold Limit Values (TLV) Remarks Not classifiable as a human carcinogen STEL 500 ppm USA. ACGIH Threshold Limit Values (TLV) Not classifiable as a human carcinogen Aldrich - W332615 Page 5 of 12 The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the US and Canada TWA 250 ppm 590 mg/m3 USA. NIOSH Recommended Exposure Limits TWA 1,000 ppm 2,400 mg/m3 USA. Occupational Exposure Limits (OSHA) - Table Z-1 Limits for Air Contaminants TWA 750 ppm 1,800 mg/m3 USA. OSHA - TABLE Z-1 Limits for Air Contaminants - 1910.1000 STEL 1,000 ppm 2,400 mg/m3 USA. OSHA - TABLE Z-1 Limits for Air Contaminants - 1910.1000 STEL 750 ppm 1,780 mg/m3 California permissible exposure limits for chemical contaminants (Title 8, Article 107) C 3,000 ppm California permissible exposure limits for chemical contaminants (Title 8, Article 107) PEL 500 ppm 1,200 mg/m3 California permissible exposure limits for chemical contaminants (Title 8, Article 107) Biological occupational exposure limits Component CAS-No. Parameters Value Biological specimen Basis acetone 67-64-1 Acetone 25 mg/l Urine ACGIH - Biological Exposure Indices (BEI) Remarks End of shift (As soon as possible after exposure ceases) Predicted No Effect Concentration (PNEC) Compartment Value Soil 33.3 mg/kg Sea water 1.06 mg/l Fresh water 10.6 mg/l Sea sediment 3.04 mg/kg Fresh water sediment 30.4 mg/kg Onsite sewage treatment plant 100 mg/l 8.2 Exposure controls Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Personal protective equipment Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Aldrich - W332615 Page 6 of 12 The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the US and Canada Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. Full contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 480 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) Splash contact Material: butyl-rubber Minimum layer thickness: 0.3 mm Break through time: 480 min Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail [email protected], test method: EN374 If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario. Body Protection Impervious clothing, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full- face respirator with multi-purpose combination (US) or type AXBEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Control of environmental exposure Prevent further leakage or spillage if safe to do so. Do not let product enter drains. SECTION 9: Physical and chemical properties 9.1 Information on basic physical and chemical properties a) Appearance Form: liquid, clear Color: colorless b) Odor No data available c) Odor Threshold No data available d) pH No data available e) Melting point/freezing point Melting point/range: -94 °C (-137 °F) - lit. f) Initial boiling point and boiling range 56 °C 133 °F at 1,013 hPa - lit. Aldrich - W332615 Page 7 of 12 The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the US and Canada g) Flash point -17.0 °C (1.4 °F) - closed cup h) Evaporation rate No data available i) Flammability (solid, gas) No data available j) Upper/lower flammability or explosive limits Upper explosion limit: 13 %(V) Lower explosion limit: 2 %(V) k) Vapor pressure 533.3 hPa at 39.5 °C (103.1 °F) 245.3 hPa at 20.0 °C(68.0 °F) l) Vapor density No data available m) Relative density No data available n) Water solubility completely miscible o) Partition coefficient: n-octanol/water log Pow: -0.24 p) Autoignition temperature 465.0 °C (869.0 °F) q) Decomposition temperature No data available r) Viscosity No data available s) Explosive properties No data available t) Oxidizing properties No data available 9.2 Other safety information Surface tension 23.2 mN/m at 20.0 °C (68.0 °F) SECTION 10: Stability and reactivity 10.1 Reactivity No data available 10.2 Chemical stability Stable under recommended storage conditions. 10.3 Possibility of hazardous reactions Vapors may form explosive mixture with air. 10.4 Conditions to avoid Heat, flames and sparks. 10.5 Incompatible materials Bases, Oxidizing agents, Reducing agents, Acetone reacts violently with phosphorous oxychloride. 10.6 Hazardous decomposition products In the event of fire: see section 5 Aldrich - W332615 Page 8 of 12 The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the US and Canada SECTION 11: Toxicological information 11.1 Information on toxicological effects Acute toxicity LD50 Oral - Rat - female - 5,800 mg/kg Remarks: (ECHA) LC50 Inhalation - Rat - 4 h - 76 mg/l Remarks: UnconsciousnessDrowsinessDizziness(External MSDS) LD50 Dermal - Rabbit - 20,000 mg/kg Remarks: (IUCLID) No data available Skin corrosion/irritation Skin - Rabbit Result: Mild skin irritation - 24 h (Draize Test) Remarks: (RTECS) Serious eye damage/eye irritation Eyes - Rabbit Result: Eye irritation - 24 h (Draize Test) Remarks: (RTECS) Respiratory or skin sensitization Maximization Test - Guinea pig Result: Not a skin sensitizer. Remarks: (ECHA) Chronic exposure may cause dermatitis. Germ cell mutagenicity Test Type: Mutagenicity (mammal cell test): chromosome aberration. Test system: Chinese hamster ovary cells Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 473 Result: negative Test Type: Ames test Test system: Salmonella typhimurium Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471 Result: negative Test Type: In vitro mammalian cell gene mutation test Test system: Mouse lymphoma test Metabolic activation: without metabolic activation Method: OECD Test Guideline 476 Result: negative Carcinogenicity Aldrich - W332615 Page 9 of 12 The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the US and Canada IARC: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. NTP: No ingredient of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP. OSHA: No component of this product present at levels greater than or equal to 0.1% is on OSHA’s list of regulated carcinogens. Reproductive toxicity No data available Specific target organ toxicity - single exposure Inhalation - May cause drowsiness or dizziness. - Narcotic effects Specific target organ toxicity - repeated exposure No data available Aspiration hazard No data available 11.2 Additional Information RTECS: AL3150000 To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. After absorption: Headache Salivation Nausea Vomiting Dizziness narcosis Coma Other dangerous properties can not be excluded. Handle in accordance with good industrial hygiene and safety practice. Kidney - Irregularities - Based on Human Evidence Skin - Dermatitis - Based on Human Evidence Kidney - Irregularities - Based on Human Evidence Skin - Dermatitis - Based on Human Evidence SECTION 12: Ecological information 12.1 Toxicity Aldrich - W332615 Page 10 of 12 The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the US and Canada Toxicity to fish flow-through test LC50 - Pimephales promelas (fathead minnow) - 6,210 mg/l - 96 h (OECD Test Guideline 203) Toxicity to daphnia and other aquatic invertebrates static test LC50 - Daphnia pulex (Water flea) - 8,800 mg/l - 48 h Remarks: (ECHA) Toxicity to algae static test NOEC - M.aeruginosa - 530 mg/l - 8 d (DIN 38412) Remarks: (maximum permissible toxic concentration) (IUCLID) Toxicity to bacteria static test EC50 - activated sludge - 61.15 mg/l - 30 min (OECD Test Guideline 209) 12.2 Persistence and degradability Biodegradability aerobic - Exposure time 28 d Result: 91 % - Readily biodegradable. (OECD Test Guideline 301B) Biochemical Oxygen Demand (BOD) 1,850 mg/g Remarks: (IUCLID) Chemical Oxygen Demand (COD) 2,070 mg/g Remarks: (IUCLID) Theoretical oxygen demand 2,200 mg/g Remarks: (Lit.) 12.3 Bioaccumulative potential Does not bioaccumulate. 12.4 Mobility in soil No data available 12.5 Results of PBT and vPvB assessment PBT/vPvB assessment not available as chemical safety assessment not required/not conducted 12.6 Other adverse effects Additional ecological information No data available SECTION 13: Disposal considerations 13.1 Waste treatment methods Product Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging Dispose of as unused product. Aldrich - W332615 Page 11 of 12 The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the US and Canada SECTION 14: Transport information DOT (US) UN number: 1090 Class: 3 Packing group: II Proper shipping name: Acetone Reportable Quantity (RQ): 5000 lbs Poison Inhalation Hazard: No IMDG UN number: 1090 Class: 3 Packing group: II EMS-No: F-E, S-D Proper shipping name: ACETONE IATA UN number: 1090 Class: 3 Packing group: II Proper shipping name: Acetone SECTION 15: Regulatory information SARA 302 Components No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302. SARA 313 Components This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313. SARA 311/312 Hazards Fire Hazard, Acute Health Hazard, Chronic Health Hazard Massachusetts Right To Know Components acetone CAS-No. 67-64-1 Revision Date 1993-02-16 Pennsylvania Right To Know Components acetone CAS-No. 67-64-1 Revision Date 1993-02-16 New Jersey Right To Know Components acetone CAS-No. 67-64-1 Revision Date 1993-02-16 California Prop. 65 Components This product does not contain any chemicals known to the State of California to cause cancer, birth, or any other reproductive defects. Aldrich - W332615 Page 12 of 12 The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the US and Canada SECTION 16: Other information Further information Copyright 2020 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale. The branding on the header and/or footer of this document may temporarily not visually match the product purchased as we transition our branding. However, all of the information in the document regarding the product remains unchanged and matches the product ed. For further information please contact [email protected]. Version: 8.3 Revision Date: 04/23/2021 Print Date: 05/23/2021